the speed has been commented enough :-)
There are two things one might want to consider along the way:
1.) there is a small chance per click to get something, like an additional ticket, or a timeskip etc. However, this seems to NOT scale with the clickpower, thus it makes more sense to use the tickets one by one.
I reallly dont like it, because this encourages to use autoclicker. but my tests (low sample size though) confirmed what they say about that on discord all the time.
2.) the game crashes a lot. if you use the ticktes one by one, its not a bad loss. However, if you go with clickpower 100 all in with all your tickets and the game crashes, you might be sad...
...however, without an autoclicker this will break your arm, dont do it one by one...