Remember to always activate the resources one by one.

There is no reason to EVER stack pompoms when you're clicking. One pom pom (at 19 clicks per second) gives 570 points. Ten pom poms will give 5700 points. There is no benefit for stacking them.

However, there is a benefit to not stacking them. If you have all your pom poms stacked, you only have one 30 second span to get bonuses (including more pom poms). However, if you use ten individually, you then have five minutes of opportunity to receive bonuses.

Usually I end up getting 1-2 bonus pom poms for ever ten I use.