From what DMM players say, the 'meta' or ideal direction to build toward shifts more into something like 'hit hard and hit fast/burst frequently'. That is, at the top end, you're focusing more towards killing quickly, which lowers the value of skillsets geared more towards survival. I like to think of it as, first you try kill something before it kills you, but if that doesn't work out, then you switch to outliving it.

For example, for water, I think that Cthulhu loses value once Vohu Manah comes out. Vohu Manah offers a huge chunk of fire atk/water resist debuff (30%) and can build up her own burst gauge faster (her abi1 gives her a 2 turn guaranteed triple atk buff and her abi2 is 'do a normal attack'). Cthulhu's offering less atk reduction, less def reduction, and her abi1 eating an orb every 9 turns is less valued compared to what else Vohu Manah has.