Attack down debuffs and damage reduction interact multiplicately--that is, they're equally effective separate or together. So there should be no loss in potency.
Apply defense up buff bonuses to the Defender DEF up box. Assist defensive passives are additive with DEF up buffs (for that character only). Passive soul bonuses to DEF are multiplicative and I haven't factored that into the calculation. Doesn't seem useful overall since most of the time you care about your weakest link, not a single character stacked with damage reduction bonuses.
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Also, make sure you're using the latest version of the spreadsheet. I'm continuously revising it, and early on there was an error in the damage reduction calculation that could have resulted in your observation about Voice of God.