Defender weapons are losing their value now that double-skill weapons offer both HP and damage output, though. They eventually gain their level 150 limit break though, that'll make them great again (assuming they get a good second skill).
Anyway, I do believe that lolix is running Experts. As such, expecting somebody to LMB everything is quite unrealistic - I'm pretty sure I didn't LMB a single thing until I was able to handle Ultimates.