From how I play counter team as main for all this time, there are mainly 3 ways to play around this team and it all depends on what kind of boss you're facing. Since you have Saffron, I'll use her as main tanker in the setup
1. Max defense: All girls has counter. This setup is recommended for bosses with multi-target hit. (Provocation won't do so well on them) All girls should have def boost buff as much as possible. The damage mainly comes from counter and occasionally skill. Hard to die, but be careful against those steroid boss. They can, and will punch through your defense.
2. Mixed offense/defense: This one is my current playstyle after Anemone got buff with her crit damage boost. Add in girl like Shiro-chan to increase crit damage/crit rate to mix and max damage from both skill and counter. (1.5x more damage with crit counter) Universally useful but can be on frail side since Shiro-chan doesn't have any skill geared towards survival.
3. Max offense: This one is strictly for enemy with super OP single target like Aqua Sakura/Ume duo. Saffron will go with provocation while the rest go full offense with boss killer skill and strongest damage/ atk buff without fear until Saffron got knocked out. Use damage negate and resurrection will help you tanking even longer but will slightly lower your atk.