Had two runs with Vine. Although she drops my Atk from gear from 30722 to 29403, I am still very impressed. Running Mordred, used Vine once on wave2 and twice on wave3, zero resists. So 6/6 so far.

Both of my wave3s were Fire though, so it's not like I would've had any issues in any case, but running -50% Def is... quite impressive. I doubt she's worth it for those running -50% through other means, but certainly a good one to use for all others.