You can take advantage of Icarus casting affliction resist down on herself after her normal overdrive if you have either or both Dark R Hime Naberius or Gacha SSR Thunder Eidolon Girimehkala to turnover or negate Icarus' healing from the 50% and 25% HP triggers.

Naberius can cast Zombie which will turn healing to damage for both the ennemy (180 sec) and your party (3 turns). If afflicted, Icarus will lose 1,000,000 HP instead of healing that amount with her triggers. Naberius can be placed in sub if your main party usually survives entirely until you reach Icarus.

Girimehkala's summons ability is the curse affliction which prevents any healing. Her effect targets the ennemy only.