from what i found out, she does the buffing on turn 1 and after losing 50% HP. this does affect orb count so if they're at full orbs, you can avoid getting nuked as long as you lower her HP to 50% or less that turn.
you can dispel the buffs with cleanse abilities (like Sol's or Cassiopeia's). one of these seems to lower regular damage, one seems to lower ability damage, and the third lowers ALL damage. you pretty much lose at least 75% of your damage output when all 3 buffs are up, but removing one can make a round of attacks suddenly do much more damage, but not the regular amount. she pretty much buff stacks to make the fight longer
best way to bypass this crap though is to just nuke the ever loving crap out of her BEFORE the buffs are on her and while they're off her. save your bursts and damaging abilities for those points... if you're strong enough, you might outright slaughter her on ultimate and even ragnarok since her HP is low
lastly, her raging nuke can debuff your combo rate in some form, but the normal nuke is more dangerous as it can outright kill two or maybe more of your team easy (if you're lucky, no one will take more than two hits, which averages out to about the damage of her raging nuke). personally, i think it's easier if you keep her out of normal, but even a tank might not save you so only sure-fire (non-paralyze) bypass is to get Awakened Gaia and have her focus skill take all the damage. she shouldn't take any damage from that as it counts as 1 attack and it defends for up to 3 attacks
other than that, do the usual, debuff atk and def on her, blind her if you can, dizzy if you can (might interrupt turns, but it does work more than usual), paralyze if you can (Thor's key skill really).





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