Originally Posted by IvanLedah21

12-5 is all-around better in rewards than 12-3 or 12-1, but is harder to clear (due to more enemies, stronger enemies, and you literally have to wade through a crap-ton of pest nodes though that last part can be a boon if you have "heal on pest node" girls in your faster squads) and also more time-consuming (12-3 can be done REALLY quick with the right setup while still having 4 chances at the far left chest which is the one that tends to get missed the most). For max chances at the top left chest, you need all 5 squads on the very top camp (due to the first chest being behind an RNG node)

All the Mission 13s win in Raid Boss spawned but are inferior for ampy farming and more time consuming than 12-1 or 12-3.

Mission 14-5 is the best for all-purpose farming, IMO. Put 3 on the top middle camp, 1 on the bottom left and 1 on left (move the left to bottom left if you don't need the extra coins, seed and boss to save time and health). If your teams are strong enough, it will go much faster than 12-5, with better XP per stamina. The one downside is you only get 2 chances at the top middle chest instead of 5 at the most-easily missed chest of 12-5 (conversely, 12-5 at least 3 chests are missable if RNG goes sour, where in 14-5, that one chest is the only one that can be missed with proper placement)

Ohh thanks for the insight!