Usually the single targets have stronger damage output. However yes they tend to be overshadowed by AOE users.
Only Single targets I use are the ones who have HP drain attached to their ability.
Just so you are aware, some single target girls do more than 1 damage to Secret garden bosses. Anthurium is one that does 2 damage I think and I know that Hannamomo (flowering peach) does 3 but she is a 6*. I know there are more 5* that do 2 instead of 1 damage tho.