Originally Posted by hypo

Well, I don't see any use to the placements except for the Top one (before the 3-way), if you don't need the cannons to shoot the pests (aka "my teams are strong enough")

Even if you're worried that your girls might be too weak, it's probably better to put only 1 girl on the right side tent, because if the second squad takes the path down to the green button, it'll release those moving pests, and you'll run into at least 2 batches of those (if you have a very fast squad with something like 850+ speed) before reaching the final boss. The little HP the boss lost from those cannons doesn't compare to the amount of damage you take from the flying pests.