It makes no difference aside from the skillblooms possibly leveling her and making the next cost more. Each skillup potential is rolled for individually by the game.

Finally have her on Skill Level 5, at least a level up was guarented when i finished the map. The 3 times i would have lost i just retreated with the 25k+ Gold from spinning around. :S
But starting all of them on the upper camp worked to erasse the 2 nests there and extend the time until the flood gates opened. Had a helper with Toad Lily just tanking the burst with just 124 Damage per Fly. From the last try i also learned that the boss has a normal single target attack and not just his aoe.
My RNG was confused.