Originally Posted by Myrdin

2 tea sets for mea s well.

I build my first team with Single target nukers Alpinia, Mei, Sakura, and added two Skill activation girls (Burning Bush and Nerine) to increase the odds of skill activation. Alpinia and Mei are both maxed out (thank you rainbow dressblooms, that we no longer get to buy for Flower Gems...).
Usually the 4th Squad clears the boss at worst, so having an Ally team as a back up is just an extra safety.

If you have a maxed Madonna, then you might want to put her as a Skill Activation girl. She has a triple-strike attack, similar to Anemone's, which may very well result in more single-target damage than (for example) Burning Bush her AOE damage, especially if you manage to get a Solar Blast off at the start of her squads' fight. Her personal trigger chance is also rediculously high for a 5*. 26%-36%, which is higher than most Rainbow girls, who generally have 24%-34%.